Relationship between the use of drugs and changes in body weight among patients: A systematic review and meta-analysis

Purpose: To investigate the impact of drugs on body weight patients.Methods: All randomized controlled trials that evaluated medications patients were searched in various databases. Studies quantifying when compared to placebo or any other treatment considered for this review. Moreover, quantitative synthesis evidence was also performed by generating forest plot.Results: A total 20 studies involving 18,547 participants included current Weight gains ranging from 0.5 2.6 kg associated with use pioglitazone, espindolol, brexpiprazole, glimepiride and ezogabine while loss 1.1 12 linked betahistine, naltrexone, bupropion, liraglutide, phentermine, topiramate, orlistat, zonisamide, duloxetine, semaglutide, metformin linagliptin. The suggested can significantly reduce -0.53 (CI 95 % -1.01, -0.04, p < 0.04) standard treatment.Conclusion: findings review suggest substantial association change during pharmacotherapy. Pioglitzone, cause gain linagliptin, duloxetine loss. Drug-induced changes might serious consequences should be addressed before initiating treatment.